February 2008 Health in the News Archive
Worrisome phthalate levels in infant urine – Babies are contaminated
February 2008
A study published in the February issue of Pediatrics reveals that "infants and toddlers exposed to baby lotions, shampoos, and powders carry high concentrations of hormone-altering chemicals in their bodies that might have reproductive effects."
A team of researchers at the University of Washington measured levels in urine from the diapers of 163 babies, aged two to 28 months. Phthalates are "found in many ordinary products including cosmetics, toys, vinyl flooring, and medical supplies." All of the samples "had detectable levels of at least one phthalate, and most had levels of several more." Notably, the "highest levels were linked with shampoos, lotions, and powders, and were most prevalent in babies younger than eight months." But, the Centers for Disease Control and Prevention says "the health effects in humans are uncertain." Still, "the results worried environmental groups that support restrictions on these chemicals."
Dr. Grout's Comment:
In 2003 a book was published by Doris Rapp, MD(H). In this book we read: "Phthalates… can cause the male offspring of rats to … have abnormal reproductive organs, while the female offspring have more miscarriages." This February 2008 article published in the journal Pediatrics outlines sources of exposure in infants, in response to recent studies on the impact of phthalates on human male reproduction. Phthalates are used in plastics, to keep the supple. They are very convenient, and were thought to be a useful product for many years. I'm not so sure that the eventual demise of the human race is worth the convenience.
Largest beef recall in US history – triggered by secret video
February 2008
The USDA announced recall of 143 million pounds of beef, the nation's largest recall to date.
The recall will affect beef products dating to February 1, 2006, that came from Chino, California's Westland/Hallmark Meat Co.
Most of the recalled beef has already been consumed. Of the 143 million pounds that were recalled, 37 million went to make hamburgers, chili, and tacos for school lunches and other federal nutrition programs, officials said.
Federal officials suspended operations at Westland/Hallmark after an undercover Humane Society of the United States video surfaced showing crippled and sick animals being shoved with forklifts and workers kicking, shocking and otherwise abusing animals that were apparently too sick or injured to walk to slaughter.
Secretary of Agriculture Ed Schafer said his department has evidence that Westland did not routinely contact its veterinarian when cattle became non-ambulatory after passing inspection, violating health regulations. "Because the cattle did not receive complete and proper inspection," he said, the government "has determined them to be unfit for human food."
Cows that cannot walk are banned for use in the food supply because they pose an added risk of mad cow disease, or bovine spongiform encephalopathy, a fatal disease that eats away at the brain.
"The longer-term problem is the inadequacies of the inspection system. How can so many downers have been mistreated day after day within a U.S.D.A. oversight system that was present at the plant?" asked Wayne Pacelle, president and chief executive of the Humane Society. "We need more boots on the ground at the plants."
Dr. Grout's Comment:
The Humane Society is to be applauded for bringing these conditions to light. If you have the stomach for it, you can watch their video at http://www.hsus.org/ This also is an argument for choosing organic beef because the animals are better treated. Organic ground beef also comes without hormones, steroids, and antibiotics.
Americans spend more to treat back pain – it isn't working
February 2008
According to new research published in the Journal of the American Medical Association, "Americans are spending more money than ever to treat spine problems, but their backs are not getting any better."
University of Washington researchers examined annual household survey data from the Agency for Healthcare Research and Quality, which was collected from about 23,000 people a year from 1997 to 2005. They also used data from related surveys of doctors and pharmacists to estimate how much money was spent on various health conditions.
Researchers found that "the average medical expenditure for respondents who said they had spine problems was 73 percent greater than that of those who didn't." After they adjusted for inflation, researchers found that "medical expenditures by Americans with back or neck problems rose an estimated 65 percent from 1997 through 2005, more rapidly than health expenditures by Americans overall." Paradoxically, however, "the estimated proportion of people with spine problems who reported having physical function limitations rose from 20.7 percent to 24.7 percent during that same period."
In terms of actual expenditures, the research team estimates that "treating spine problems in the United States costs $85.9 billion a year, rivaling the economic burden of treating cancer, which costs $89 billion."
Study co-author Richard A. Deyo, M.D., M.P.H., said patients with pain have "reported more work limitations and poorer functioning in 2005 than in 1997," which indicates that "we're overtreating a lot of people, and we're providing a lot of services that may not be very beneficial." Dr. Deyo further notes that "the evidence [for surgery] is at best murky and confusing." In addition, Dr. Deyo stated, "patients need to recognize that" drugs such as Vicodin (hydrocodone bitartrate and acetaminophen) and OxyContin (oxycodone HCl) "have many potential side effects, including drowsiness, persistent constipation, and sexual dysfunction." And, he said, "We still don't know much about their long-term efficacy and safety for chronic back pain."
Dr. Grout's Comment:
How sad, that we spend all this money on drugs, when acupuncture is proven to be so effective at treating back pain (and other pains as well). Acupuncture is inexpensive and effective – why look any further, if you don't have to? It should definitely be a first choice, not a last resort.
FDA issues Botox & Chantix warnings – aggressive behavior and deaths reported
February 2008
The FDA today notified the public that Botox and Botox Cosmetic (Botulinum toxin Type A) and Myobloc (Botulinum toxin Type B) have been linked in some cases to adverse reactions, including respiratory failure and death, following treatment of a variety of conditions using a wide range of doses.
In an early communication based on the FDA's ongoing safety review, the agency said the reactions may be related to overdosing. There is no evidence that these reactions are related to any defect in the products.
The adverse effects were found in FDA-approved and nonapproved usages. The most severe adverse effects were found in children treated for spasticity in their limbs associated with cerebral palsy. Treatment of spasticity is not an FDA-approved use of botulism toxins in children or adults.
The adverse reactions appear to be related to the spread of the toxin to areas distant from the site of injection, and mimic symptoms of botulism, which may include difficulty swallowing, weakness and breathing problems.
On February 1st, the FDA asked Pfizer, the manufacturer of Chantix, to update the Chantix prescribing information to include warnings about the possibility of severe changes in mood and behavior. Chantix is used to help patients stop smoking.
Chantix may cause worsening of a current psychiatric illness even if it is currently under control and may cause an old psychiatric illness to reoccur. Symptoms may include anxiety, nervousness, tension, depressed mood, unusual behaviors and thinking about or attempting suicide.
Dr. Grout's Comment:
The FDA is not advising health care professionals to discontinue prescribing these products. This kind of reaction from a government over-sight agency fuels the debate whether industry has too much influence upon the regulatory process at the FDA. At the very least, these are two more events in an on-going tide of bad news about adverse drug reactions. And these drugs are optional, so why take the risk?
Stunning reversal on food additives – AAP says hyperactivity is real
February 2008
The American Academy of Pediatrics (AAP) has made a stunning reversal of its long standing position that dietary treatment is of no use in AD/HD. The AAP acknowledged findings of last September's Southampton/McCann study which demonstrated that common food colorings, derived from petroleum, and common preservatives cause hyperactivity in children.
In AAP's February 2008 issue of Grand Rounds, editors said:
"…this was a carefully conducted study in which the investigators went to great lengths to eliminate bias and to rigorously measure outcomes … the overall findings of the study are clear and require that even we skeptics, who have long doubted parental claims of the effects of various foods on the behavior of their children, admit we might have been wrong."
This opens the door to new AAP guidelines:
"Despite increasing data supporting the efficacy of stimulants in preschoolers with attention deficit hyperactivity disorder (AD/HD) parents and providers understandably seek safe and effective interventions that require no prescription … practitioners faced with hyperactive preschoolers have a reasonable option to offer parents. For the child without a medical, emotional, or environmental etiology of AD/HD behaviors, a trial of a preservative-free, food coloring–free diet is a reasonable intervention."
Dr. Grout's Comment:
AAP is the organization whose responsibility includes writing practice parameters which are guidelines for pediatricians to use in treating children. For most of the past 30 years, the AAP has maintained that dietary treatment is of no use in AD/HD.
This is a long-overdue, but extremely welcome reversal of position. Of course food matters! Children also consume food dye in their toothpaste, their shampoo (through the scalp), their hand lotion (through their skin), their cereal, their juice drinks, their mac 'n cheese, etc. In 1977 study, the National Academy of Sciences determined that most people in the United States eat up to an average of 317 mg of food dyes per day. You can read more at Kid Food - What is It? and Soda Pop-Obesity and Hyperactivity in a Can.
Vinyl toys unpopular – retailers respond to safety concerns
February 2008
After recalling millions of toys to protect consumers from lead paint, toy makers face growing pressure over the plastic PVC - commonly known as vinyl - found in a myriad of playthings.
The Wall Street Journal reports some of the first plastic toys made without PVC will be shown at the world's largest toy trade show, the American International Toy Fair, which opens Sunday in New York.
Depending upon how it is made, PVC frequently contains lead or other toxic materials. Vinyl chloride, used to make PVC, has been identified as a carcinogen. Phthalates are often used to soften PVC-made toys and it has been linked to developmental and hormonal disruptions in children.
In 2003, The Consumer Product Safety Commission denied a petition from environmental groups to ban PVC in toys saying it didn't believe children chew on PVC toys long enough to cause harm. The Toy Industry Association says PVC in toys poses no safety risks.
Dr. Grout's Comment:
Here we see yet another case where concerned parents and environmental groups are taking the lead, putting pressure on toy manufacturers to lessen the body burden of chemicals. And the marketplace is responding. Phasing out PVCs is do-able. Because of proprietary concerns, we are not hearing yet much about the safety of what will be used instead. But one thing is clear: Where our children are concerned, safety should be everyone's first priority.
Fluorescent lights release toxic mercury – campaign to switch has problems
February 2008
There is an international campaign to ban the incandescent bulb in favor of alternative sources of lighting, most notably fluorescents. Unfortunately, fluorescents contain noxious chemicals including argon and mercury that are contaminating the environment.
As Mike Adams of naturalnews.com reports, 800 million lamps produce enough mercury to contaminate about 20 million acres of water.
When the bulbs break, mercury can contaminate the environment, including soils, people and animals in the surrounding the area. Mercury is a potent neurotoxin that can severely harm the human nervous system through either ingestion, inhalation or skin absorption. It is a highly toxic heavy metal that acts as a cumulative poison similar to lead or DDT.
When the bulbs are recycled, a special hazardous waste company generally carries out the process of collecting the unbroken bulbs, crushing them and capturing both the remaining mercury gas and the spent mercury solids. These companies then ship the mercury-bearing waste, using an EPA-permitted hazardous waste transporter, to an EPA-approved hazardous waste treatment, storage and disposal facility.
Most compact fluorescent lights simply end up in landfill and are not recycled at all. Consumers simply throw them in the trash.
Dr. Grout's Comment:
Here is a case of the road to good intentions being paved with 3rd-rate planning. The EPA launched a campaign to get us to switch to fluorescent light bulbs in the name of energy savings. But they did not launch a safety education campaign at the same time. And most of all, they ignored the inherent and significant risk mercury presents to human health.
Most consumers couldn't tell you they are supposed to dispose of the compact fluorescents through "hazardous waste collection days" or certified waste recycling centers. And odds are, the bulbs will break before you get them there – light bulbs are fragile!
Meanwhile - Norway, Sweden, Finland and Denmark have stated they intend to eventually eliminate mercury use completely, and plan on researching alternatives to fluorescent lighting such as LED technology.
Infertility helped with acupuncture – successful and inexpensive
February 2008
According to findings published in today's issue of the British Medical Journal, "acupuncture might improve the odds of conceiving if done right before or after embryos are placed in the womb." Lead author Eric Manheimer, M.S., a researcher at the University of Maryland School of Medicine, and colleagues, conducted a meta-analysis of results from seven studies on 1,366 women in the United States, Germany, Australia, and Denmark who are having in vitro fertilization (IVF). Participants "were randomly assigned to receive IVF alone, IVF with acupuncture within a day of embryo transfer, or IVF plus sham acupuncture, in which needles were placed too shallowly, or in spots not thought to matter … three of the studies [considered] acupuncture beneficial," another "three found a trend toward benefit, and one found no benefit."
By combining study results, the researchers discovered a 65 percent increase in pregnancy, and an 87 percent increase in the continuity of the pregnancy. The results also showed a 91 percent increase in live births.
The analysis indicated that in studies where pregnancy rates were high, the benefit of acupuncture was small and non-significant. Manheimer noted that while "[a]cupuncture may be useful adjuvant treatment in the IVF process," he believes "there needs to be more studies to confirm these findings, because they are still preliminary."
Nevertheless, authors concluded that even if the likelihood of success with acupuncture were small, an acupuncture cointervention may still be cost effective, considering the negligible costs of two to four sessions of acupuncture, relative to the high costs of in vitro fertilization.
Dr. Grout's Comment:
There are at least two acupuncturists in the Phoenix area who do acupuncture for fertility, both with great success. One is Pamela J. Wallach, LAc who practices out of our office. The other is Rebecca Wilks, MD, MD(H) whose office is in Glendale. Both report markedly increased rates of pregnancy after in-vitro fertilization, and excellent results even with patients who do not have IVF, but whom acupuncture helps conceive naturally. Acupuncture is certainly both less expensive and less dangerous than IVF. And when combined with excellent nutritional advice and appropriate vitamin and nutrient supplementation, what better start could a baby have?
Environmental chemicals bad for sex life – Damage is passed through generations
February 2008
Common household chemicals and widespread pollutants are changing male reproductive health and impacting sexual function, development and cancer rates of today's generations and possibly their offspring, according to more than 15 years of research by a Colorado State University expert. For example, one study looking at sperm counts globally from 1940 - when chemicals first began to be widely produced - to the 1990s, indicates a 1.15 percent per year decline in sperm counts. These declines may be linked to chemical exposure.
Chemicals including insecticides, pesticides, common pollutants in ground water, and chemicals in plastics, make-up and nail polish are on a growing list of culprits causing developmental abnormalities such as hypospadias and cryptorchidism, impaired sperm quality and impotence. Reproductive health can be compromised if males are exposed at various times in life spanning from in utero up to adulthood.
Some of these chemicals can survive in the environment for 30 to 40 years, and the chances for exposure are high because the chemicals have permeated our world. The incidence of testicular cancer in young men 15 to 35 years old has increased three to four fold over the past 50 years, particularly in the Western world. Erectile dysfunction is reported in one-third of the U.S. male population.
Dr. Grout's Comment:
These chemicals affect the body through several channels. They attach to receptors in the body that help hormones carry out their functions and either block actual hormones from attaching or mimic the expression of the real hormones, causing confusion in the male body. In addition, some interfere with the body's natural production of hormones.
There is also evidence that exposure today to some of these chemicals can affect the reproductive health of this generation as well as the future health of offspring of those exposed. Watch a fascinating BBC program, called The Ghost in Your Genes.
Give up multivitamins - Harvard warns
February 2008
According to Harvard Men's Health Watch, recent studies have linked multivitamin use to prostate cancer.
"Scientists have many unanswered questions about folic acid and cancer. One popular theory, still unproven, suggests that timing and dose may explain folate's apparently contradictory effects on cancer," researchers said.
Multivitamin/mineral supplements are regularly taken by over one-third of American adults. The news could strike a damaging blow to the multivitamin market if consumers stop buying multivitamins which contain folic acid.
Harvard suggested the average man could give up the multivitamin, at least until scientists solve the puzzle of folic acid and cancer.
They said: "There is no proof that a daily multi vitamin is harmful. Still, it now seems possible that the high levels of folic acid achieved by well-intentioned people who take a multivitamin and eat healthful foods could increase the risk of colorectal and possibly prostate and breast cancers."
Harvard added that if men stop taking a multivitamin, they should consider taking a vitamin D supplement. This is because the typical diet for most men and women does not supply enough of this vitamin, Harvard said.
Dr. Grout's Comment:
There is a key piece of information missing in the news reports: what kind of folic acid is in your supplement? Folate is the water-soluble B vitamin that occurs naturally in food. Folic acid is the synthetic form of folate and a cheap version of it is often found in supplements and added to fortified foods. A third type is methyltetrahydrofolate, (MTHF), the predominant form of folate in cerebrospinal fluid. Low CSF MTHF levels are associated with inborn errors of metabolism affecting folate metabolism and in dietary deficiency of folate.
This vitamin's primary job is to maintain the cells' genetic code, regulate cellular division, and transfer chromosomes form one cell to another. There is some evidence that a deficiency of folate can cause damage to DNA that may lead to cancer.
Folate maintains optimal function of the detoxification pathway and it needs the catalysts vitamins B12, B6 and vitamin C to carry out its functions effectively.
There is evidence that your body can reject synthetics. Even the allopathic community has noted that synthetic vitamin E is a poor substitute for the real thing and does little to boost your health. But the debate is unsettled about synthetic folic acid. According to Aileen Burford-Mason, president of the Holistic Health Research Foundation of Canada, "some people genetically are not equipped to cleave the folate out of food and convert it to folic acid. It's only well utilized by about 70 per cent of the population. But there is a synthetic form called methyltetrahydrofolate that 100 per cent of people can use."
Vitamins in isolation, without any knowledge of what else is going on in the system, may not be totally harmless. It is possible that DNA may be turned on (or off) by methyl groups (which folic acid supplies). If the rest of the system is unhealthy, or contains multiple foods/chemicals/drugs which are carcinogenic, then perhaps indeed there may be an association between turning off some DNA and getting cancer. It's actually the old "post hoc ergo propter hoc" argument – because B follows A, that does not necessarily mean than A causes B – B may in fact be caused by some as yet unmeasured C or D that we haven't considered. I think the Harvard study is making unwarranted conclusions.
FDA approves Nexium for kids – aged 1-11 years old
February 2008
The FDA has approved use of the drug Nexium (esomeprazole magnesium) manufactured by AstraZeneca, in children aged one to 11 who have gastroesophageal reflux disease (GERD). The agency "approved liquid and delayed-release capsules of Nexium in doses of 10 milligrams or 20 milligrams for these youngsters." Nexium is part of a class of drugs known as proton pump inhibitors that decrease the amount of acid produced in the stomach, and help heal erosion in the lining of the esophagus."
The FDA's "approval was based on an extrapolation of data from adult studies as well as safety and pharmacokinetic studies performed in pediatric patients.
Common side effects of the drug when used in this age group included "headache, diarrhea, abdominal pain, nausea, gas, constipation, dry mouth, and fatigue."
Dr. Grout's Comment:
Are we completely insane??? One year old? Nexium? Esomeprazole works by blocking acid production in the stomach. GERD is a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus. I remember we were taught in medical school how dangerous these drugs are. Now the FDA is recommending that instead of teaching mothers how to feed their children properly, we just feed youngsters a purple pill to shut down the stomach's natural ability to produce acid to digest food.
I am always glad to see that people can still figure things out though. Here's what one post on medheadlines.com had to say:
"Whenever my daughter has acid reflux, I give her 1 teaspoon of apple cider vinegar. It works instantly. Our nation is drugged from cradle to grave by harmful pharmaceutical drugs. We've become a nation of drug addicts, and many have died as a result (e.g. Heath Ledger). How ignorant of all of us to believe that every ailment imaginable can be fixed with a pill…"
Combo vaccine linked to seizures, fever – chickenpox and MMR
February 2008
According to data presented to the meeting of the Advisory Committee on Immunization Practices, children suffered higher rates of fever-related convulsions when they got a Merck & Co. combination vaccine instead of two separate shots. Specifically, the Centers for Disease Control and Prevention-funded study found that for "children ages 12 months through 23 months, the rate of seizures was twice as high in toddlers who got ProQuad, compared with those who got one shot for chickenpox, and one for the three other diseases:" measles, mumps, and rubella.
Merck officials said there was five times more chickenpox antigen, the key ingredient, in the vaccine than in the stand-alone chickenpox shot. But, it remains to be seen if that explains the seizure phenomenon. Although the federal panel "had previously taken a position that they preferred doctors give children as few needle sticks as possible," this finding has prompted them "to water down their preference for the combo vaccine."
Dr. Grout's Comment:
Shall parents decide between one more unnecessary shot, or seizures? Absurd choices. I for one do not recommend giving children the MMR vaccine at all.
CDC says annual flu vaccine is for children - aged six months to 18 years
February 2008
NBC Nightly News reported that although "this year's flu vaccine doesn't work all that well, a federal panel came out with a broad new recommendation about flu vaccines."
The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practice "wants every child from six months to eighteen years, to get a flu shot [each year], starting with the 2009 flu season."
Currently, the CDC recommends the flu shot for children five and under. But, this new recommendation could change that drastically. The Los Angeles Times points out that an estimated 30 million more children would be vaccinated. While the shots would not be mandatory, "the federal imprimatur would make physicians more likely to offer the vaccine to children."
In making the recommendation, the panel sought "to reduce both the time children and parents lose from visits to pediatricians and missing school, and the need for antibiotics for complications. The CDC expects that the vaccine industry, which made 132 million doses available this year, will be able to produce a sufficient supply in future years. If the CDC adopts the panel's recommendation, it would be one of the largest expansions in flu vaccination coverage in U.S. history."
While many healthcare professionals and parents applauded the panel's recommendation, others criticized it. Rita Shreffler, executive director of the National Autism Association, stated, "The CDC continues to minimize the dangers of injecting mercury and aluminum into our kids."
Dr. Grout's Comment:
So maybe if we give the dysfunctional vaccine more often it will work better?
Government Concedes 1st Vaccine-Autism Case in Court - Now What?
February 2008
After years of insisting there is no evidence to link vaccines with the onset of autism spectrum disorder (ASD), the US government has quietly conceded a vaccine-autism case in the Court of Federal Claims. The unprecedented concession was filed on November 9, 2008, and sealed to protect the plaintiff's identify.
Doctors conceded that the child was healthy and developing normally until her 18-month well-baby visit, when she received vaccinations against nine different diseases all at once (two contained thimerosal).
Days later, the girl began spiraling downward into a cascade of illnesses and setbacks that, within months, presented as symptoms of autism, including: No response to verbal direction; loss of language skills; no eye contact; loss of "relatedness;" insomnia; incessant screaming; arching; and "watching the florescent lights repeatedly during examination."
In its written concession, the government said the child had a pre-existing mitochondrial disorder that was "aggravated" by her shots, and which ultimately resulted in an ASD diagnosis. The girl and her family will now be compensated for the lifetime of care she will require. But its implications for the larger vaccine-autism debate, and for public health policy in general, are not as certain.
The claim is one of 4,900 autism cases currently pending in Federal "Vaccine Court."
Dr. Grout's Comment:
This news has been so quiet that almost the only person reporting it to date is David Kirby, author of the book, Evidence of Harm, which speaks to thimerosal (mercury) in vaccines. Kirby's full report can be read at http://www.huffingtonpost.com/david-kirby/government-concedes-vacci_b_88323.html
Saturday Night Live Spoofs Drug Ads – Seasonale
February 2008
At a time when the drug industry is facing increasing criticism, the cast of "Saturday Night Live" has weighed in with a hilarious spoof of television drug ads.
The "commercial," modeled after the real advertising campaign for the birth control pill Seasonale, touts a fake pill, Annuale. The spoof uses similar pill packaging, actors and even the same pink chairs, sneakers and yoga mats depicted in the real ad.
Dr. Grout's Comment:
Here's the video:
http://well.blogs.nytimes.com/2008/02/25/saturday-night-live-takes-on-drug-ads/
Vaccine Companies Investigated for Manslaughter - Hep B vaccine
February 2008
According to Reuters, a formal investigation has been launched by French authorities against two managers from drug companies GlaxoSmithKline and Sanofi Pasteur. A second investigation for manslaughter has also been opened against Sanofi Pasteur MSD.
The investigations are in response to allegations that the companies failed to fully disclose side effects from an anti-hepatitis B drug used between 1994 and 1998.
During this time, close to two-thirds of the French population, and almost all newborn babies, received a hepatitis B vaccine. The vaccination campaign was halted after concerns rose over the shot's side effects.
Thirty plaintiffs, including the families of five people who died after the vaccination, have launched a civil action in the case against the drug companies.
Dr. Grout's Comment:
The main risk factors for hep B are IV drug abusers and those who engage in sex with multiple partners. So unless that describes the mother, why on earth would the baby need a hep B vaccine? Yet the shot is recommended for every baby born in a US hospital; parents need to know enough to refuse.
The immune and central nervous systems of a newborn infant simply are not ready to handle something as challenging as a vaccine. In most other countries, the hep B vaccine is given later in life. Even then, this vaccine is associated with numerous side effects including increased risk of multiple sclerosis and rheumatoid disease – autoimmune diseases.
Diabetes study suddenly halted – deaths from low blood sugar
February 2008
For decades, researchers believed that if people with diabetes lowered their blood sugar to normal levels, they would no longer be at high risk of dying from heart disease. But the New York Times reports a major federal study of more than 10,000 middle-aged and older people with type 2 diabetes has found that lowering blood sugar actually increased their risk of death, researchers reported Wednesday.
The researchers announced that they were abruptly halting that part of the study, whose surprising results call into question how the disease, which affects 21 million Americans, should be managed.
Among the study participants who were randomly assigned to get their blood sugar levels to nearly normal, there were 54 more deaths than in the group whose levels were less rigidly controlled. The patients were in the study for an average of four years when investigators called a halt to the intensive blood sugar lowering and put all of them on the less intense regimen.
Even though most people assumed that lower blood sugar was better, no one had rigorously tested the idea.
And there are troubling questions about what the study means for people who are younger and who do not have cardiovascular disease. Should they forgo the low blood sugar targets?
No one knows.
Dr. Grout's Comment:
Maybe you shouldn't fool with Mother Nature by using drugs etc to lower blood sugar. Maybe we should look at the diet, which has been proven to lower blood sugar and restore normal response of muscles to insulin.
Humira for juvenile rheumatoid arthritis - FDA gives approval
February 2008
Abbott Laboratories announced that its top-selling drug, Humira (adalimumab), has won approval from federal regulators to treat juvenile rheumatoid arthritis (RA). According to Abbott, "This is the sixth use for Humira approved by the Food and Drug Administration (FDA), and the second this year."
Humira "is approved in the U.S. to treat rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis, a spinal disorder; psoriasis; and Crohn's disease, a bowel disorder."
The FDA's approval was based on a study that found children with the disease were twice as likely to achieve 70 percent improvement of their symptoms as patients receiving a placebo, and were about a third less likely to experience a flare-up of the disease.
RA "is a condition in which inflammation causes joints -- usually including the hands and feet -- to become inflamed." Furthermore, the "painful swelling often leads to destruction of joints."
Dr. Grout’s Comment:
Humira is a Tumor Necrosis Factor (TNF) blocker. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis. In order to block the inflammatory response, are you willing to subject your child to side affects which include tuberculosis, invasive fungal infections, certain types of cancer (especially lymphoma), and autoimmune disorders (such as a lupus-like syndrome)? Humira is in the class of immunosupressants. Doesn't it make more sense to discover the sources of inflammation, and eliminate those? It would be less expensive for the families, and would promote a lifetime of heath, instead of a lifetime of disease management.
Leaky Gut Syndrome can definitely be a cause of Juvenile Rhuematoid Arthritis. With leaky gut, the common diet of processed food, antibiotics, and stress can set off a cascade of problems in the gut with inflammation of the gut lining causing swelling and separation of cells, allowing large molecules to leak into the blood stream. Some of these molecules look like our own proteins, and this can result in inflammation of the joints. Leaky gut must be addressed with diet or other problems will follow. Adults can experience the same phenomenon. It may also be called rheumatoid arthritis in adults. Seldom is the connection made between the gut and the joints, since these body systems are treated by different practitioners, in the conventional medical practice.
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